Having ended the hoodoo against their North London rivals at the tail end of last season, Tottenham have a right to feel confident as they head to the Emirates for the Saturday lunchtime clash.
At 15/4 with sportingbet, Spurs look a big price against a side now widely considered an equal and the hosts have been particularly welcoming to the likes of West Brom and Newcastle already this season.
The draw might also look tempting to positive punters at 11/4, especially with the derby bragging rights likely to weigh heavy on both teams' shoulders, while the less optimistic might consider the 3/5 on Arsenal as a little insurance.
Talking of insurance, sportingbet have brought back their Late Goal Heartache promotion by popular demand, meaning that whichever team you fancy this weekend, you'll be spared the pain if the result swings against you in the dying minutes.
Simply bet on the Match Prices to qualify and if your bet is winning at 85 minutes, you can breathe easy knowing that even if a late strike costs you, we'll refund your stake as a free bet.
We've got over 60 markets for this clash, however, so don't feel restricted to one. This match-up has proved a high scoring affair in recent times, so the Over/Unders look a great place to start.
Over 2.5 Goals at 3/5 is surely nailed on if you think the last three meetings are anything to go by, and that's not even taking the infamous 4-4 of 2008/09 into consideration!
If you see another high scoring thriller on the horizon, you can plump for a bigger price with Over 3.5 Goals available at 33/20 and Over 4.5 a 4/1 shot.
If you prefer to back goalscorers, then Gareth Bale to continue his love affair with the big games and notch the first goal is priced 11/1, Rafael van der Vaart to produce the goods again is 7/1 and for an outside bet, you might consider William Gallas to torment his old club with a 9/1 strike at any time!
As ever the Sportingbet Podcast has got the match coupon previewed in full, along with the rest of the Premier League programme and a look through the Ashes Outright markets.
The chance to win a £50 Free Bet is on offer again thanks to Steve Bull's quiz question, so don your thinking cap and tune in today!
Odds correct at time of writing...