Big Sol was replaced by Wes Brown just before the half-hour mark after falling awkwardly on his ankle after an aerial challenge.
Sol admitted: "It's very much doubtful for Saturday. I went for the header and went over and his body weight came across as well and it (his ankle) just twisted."
England won the Group Nine clash 3-1 thanks to goals from Michael Owen, Paul Scholes and Andy Cole.
Meanwhile Sergei Rebrov was substituted at half-time during Ukraine's 1-1 draw against Wales in Cardiff.
Sol Campbell has admitted he has to be doubtful for Saturday's Premiership derby at Arsenal after limping out of England's win in Albania on Wednesday night.