Adam Smith played his part in England's goal but the Young Lions suffered a rare defeat in Belgium on Monday night.
The full-back earned his fourth cap at Under-21 level and started his third-successive European Championship qualifier in Mons.
It all started well as Adam burst down the right in the 14th minute only to be upended by Jimmy De Jonghe. Liverpool's Jordan Henderson curled in the free-kick which was powered home by his team-mate Martin Kelly.
England continued to dictate possession into the second half but the home side equalised through Jens Naessens in the 72nd minute.
As Stuart Pearce's team pushed on for a late winner they were caught out as Gary Gardner misplaced his pass intended for Adam, Ziguy Badibanga latched onto it and raced into the box and struck the post only for Omar El Kaddouri to slot home the rebound.
Tom Carroll didn't make it into the 18 on the night.
Having won their first four matches, England remain in control in Group Eight and top by four points from Belgium.
Elsewhere in European U21 qualifying on Monday night, goalkeeper Jordan Archer, currently on loan at Bishop's Stortford, was on the bench as Scotland achieved a fine 2-1 win in Holland in Group 10.