We progressed from our qualifying group with seven points while the Czech side finished third in their Champions League group, which included Arsenal.
The tie will be a repeat of last season's qualifying round clash, which we won 2-0 on aggregate.
The first leg is provisionally scheduled to be played on Thursday February 14 (TBC), with the return leg the following week.
Should we progress from the round of 32, we will face the winners of the tie between PSV Eindhoven and Helsingborgs IF in the last 16, with the first leg to be played at White Hart Lane.
We have been drawn against Slavia Prague in the round of 32 of the UEFA Cup, with the first leg to be played away from home.