We booked a place in the last 32 of the competition with a 1-1 draw against the Belgian side at the Constant Vanden Stock Stadium.
After a nondescript first half, the game livened up after the break.
Anderlecht took the lead in the 68th minute when Bart Goor capitalised on defensive hesitancy on the edge of our penalty area.
However, the lead only last a couple of minutes as Jermaine Jenas was upended by Jelle Van Damme and Dimitar Berbatov slotted home from the penalty spot.
Both keepers made fine saves after that - Paul Robinson to deny Cyril Thereau, Daniel Zitka tipped over a dipper from Jermain Defoe - and the final 1-1 scoreline means we'll finish no worse than second in Group G with the final round of matches to follow on December 19.
"I'm happy with the points because this means qualification, especially considering the defeat (in the first group game) against Getafe," said Head Coach Juande.
"Anderlecht did well, they were after the three points and performed well.
"I didn't think we deserved to go behind because we were in control of the game and it was only a momentary lapse of concentration that let Anderlecht in. The way we reacted to that gave me great satisfaction."
Didier Zokora partnered Michael Dawson in a new central defensive role as he turned the clock back to a position he played earlier in his career. "I wanted to use his experience in that position and he did well," added Juande. "He concentrated, he controlled the attacks well even though we conceded a goal and overall I was happy with his performance."
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Juande Ramos was pleased with how the lads responded to going a goal behind to clinch the point required for progress in the UEFA Cup against Anderlecht on Thursday night.