The one-off game between the Northern and Southern section champions will kick-off at 7.30pm.
United clinched the Northern section of the league without kicking a ball when title rivals Aston Villa suffered a 2-1 defeat against Leeds United on Thursday night.
Our reserves completed their league campaign with a 3-1 win at Coventry City on Tuesday night.
Clive Allen's squad stormed to the title with a run of 16 wins in their final 18 matches - clinching it by a clear 12 points.
Our reserves will take on Manchester United at Old Trafford in the Barclays Premiership Reserve League Play-Off Final next Thursday, May 4.