Our Irish star was stretchered off after 28 minutes of this high-octane 'warm-up match' in front of over 35,000 fans at Ibrox.
Keane, on target at Sheffield United on Sunday, suffered an ankle injury as Rangers defender Marvin Andrews blocked his attempted shot.
He signalled to the bench straight away, clutching his ankle, and our medical team soon waved for a stretcher. He was carried off with his right leg stabilised in a protective brace.
It means Head Coach Santini has lost THREE strikers in pre-season with youngsters Lee Barnard (broken collar bone/ankle) and Jamie Slabber (shoulder) already crocked. Fredi Kanoute is yet to play but has stepped up training after illness last week.
Michael Brown and Stephen Kelly have also picked up injuries and to add injury to, well, injury, Dean Marney limped off later on at Ibrox with a gashed knee.
It was a fiesty friendly - summed up by Sean Davis and Nacho Novo's bust-up after a crunching 50-50 tackle in the second half - but despite defeat, and Keane's injury, it was the sort of test to bring the lads on further with our Premier League opener against Liverpool drawing ever closer.
The game actually started quietly with the likes of Pedro Mendes and Davis popping the ball about but Rangers started to get on top about midway through the first half.
Paul Robinson made a magnificent point-blank save to deny the impressive Dado Prso and after Ledley King flicked a header just wide from John Jackson's corner, Rangers took the lead.
Unfortunately it came via a mistake as King and Anthony Gardner got tangled up allowing Novo a clean run on goal - he made no mistake one-on-one.
Keane's injury put even more of a dampener on procedings but we responded well with more decent possession before Stefan Klos acrobatically clawed away Jermain Defoe's snapshot. Defoe continues to look sharp.
Rangers stepped up a gear though and Robinson somehow kept out Andrews' header but it wasn't long before the lead was doubled. Lovenkrands broke through Carr's tackle, sprinted to the byline and crossed for Prso to tap home with Robinson helpless.
The second half didn't reach the intensity of the first. Novo blazed over from close range after the best move of the half but the action was stop-start thanks to a succession of substitutes.
7mins: First serious attack, Ricketts fed Carr on overlap but Vanoli back to shepherd ball home to Klos.
10mins: Mendes left short by Gardner, hustled out, Rae dragged shot wide from 28 yards.
17mins: Vanoli blasted free-kick into the crowd.
19mins: SAVE. Fantastic save from Robinson. Vanoli corner swung in from right, Prso free header, eight yards out, Robinson point-blank tip over the bar.
22mins: CLOSE. King rose unchallenged to meet Jackson corner, 10 yards out, flicked header just wide.
24mins: GOAL. King and Gardner got tangled up, Novo suddenly through one-on-one and finished clinically across Robinson into bottom left corner. 0-1.
28mins: INJURY. Carr into Ricketts, squared to Keane, superb block tackle from Andrews as he attempted shot. Keane clutched right ankle straight away, stretchered off with right leg stabilised in brace.
29mins: SUB. Marney on for Keane, Ricketts pushed up to partner Defoe.
34mins: Delightful clip over the top from Davis to Ricketts, in box, couldn't control.
36mins: Superb defensive header from King to deny Prso as he went for Lovenkrands' hanging cross at far post.
37mins: SAVE. Snapshot from Defoe from 18 yards clawed out of the air by acrobatic Klos.
39mins: SAVE. Another point-blank block from Robinson, this time with his legs, superb reactions to keep out close-ranger Andrews' header from Ricksen free-kick.
44mins: GOAL. Lovenkrands broke through Carr tackle, continued to byline, whipped in low cross tapped in by Prso at far post. 0-2.
Half-time: Rangers 2, Spurs 0
Half-time: SUB. Vignal for Vanoli.
49mins: Defoe attempted free-kick block by wall that stood about three yards away.
51mins: MISS. Lovenkrands jinked past Marney, inside to Novo, stole a yard from Gardner only to blaze great chance over from 10 yards.
60mins: Goal-bound Novo volley blocked bravely by King.
63mins: SUB. Mabizela for Mendes.
65mins: SUB. Arveladze for Novo.
66mins: Decent interplay between Ricketts and Defoe but Boumsong back to hack the ball away from Defoe.
69mins: SUB. Thompson for Prso.
75mins: SUB/INJURY. Marney limped out of action with gashed knee after Lovenkrands tackle. Replaced by Hughes.
77mins: SUB. Doherty for Davis.
82mins: Thompson chipped just over.
83mins: SUBS. McKie for Gardner; Hutton for Ricksen.
85mins: CHANCE. Ricketts miscued from 15 yards, ball came back to him, fired over the top.
89mins: SUB. Ross for injured Lovenkrands.
Line-ups: Rangers: Klos, Ricksen (Hutton, 83), Vanoli (Vignal, 45), Boumsong, Andrews, Rae, Burke, Hughes, Prso (Thompson, 69), Novo (Arveladze, 65), Lovenkrands (Ross, 89). Subs: Smith, Khizanishvili, Malcolm.
Spurs: Robinson, Carr, Bunjevcevic, Davis (Doherty, 77), Gardner (McKie, 83), King, Ricketts, Mendes (Mabizela, 63), Defoe, Keane (Marney, 29; Hughes, 75), Jackson. Unused sub: Keller.
Referee: Michael McCurry.
Jacques Santini's dreadful luck in pre-season continued with another injury - this time Robbie Keane - in Wednesday night's friendly against Rangers.