The big Swiss defender has lost his place in the first team to youngster Alton Thelwell and, after a couple of appearances as a non-playing substitute, will get some much-needed action against West Ham.
Once again it is a strong-looking reserve outfit with a blend of experience and youth.
Six of the starting line-up have featured in the Premiership this season with Ian Walker in goal, Vega, Gary Doherty, Simon Davies, Matthew Etherington and Willem Korsten, who came on at Old Trafford on Saturday, all in the side.
Antony Gardner also plays alongside younger pros Ian Hillier, Ciaran Toner and John Piercy while Under-19 midfielder John Jackson gets another chance at reserve team level.
Manager Chris Hughton said: “Young John Jackson will come into the frame which is a real bonus for him and us — this is a lad who has played for England Under-18s on a few occasions.
“John Piercy is also back in the frame after breaking a bone in his thumb.
“By the usual standards of reserve team football we’ve been quite lucky. There are normally a lot of chops and changes but we’ve managed to be fairly consistent for the last seven or eight games, which is good.”
Spurs Reserves: Walker, Hillier, Gardner, Toner, Vega, Doherty, Davies, Jackson, Piercy, Korsten, Etherington.
Listen to Chris' pre-match interview here
Ramon Vega is on reserve duty at St Albans on Tuesday night.