Heung-Min Son and Dele Alli both hit the woodwork before Harry Kane powered home a header after Christian Eriksen's corner was flicked on by Son with 12 minutes remaining.
That proved to be the game's only goal and was enough to secure our progression into the round of 32 with one group game to spare.
Qarabag (4-2-1-3): Sehic, Medvedev, Huseynov, Sandygov, Agoli (Armenteros 55); Garayev, Almeida; Quintana; Taghiyev (Chumbinho 65), Poepon, Ismayilov (Mammadov 80). Substitutes (not used): Veliyev, Michel, Gurbanov, Yunuszada.
Spurs (4-2-3-1): Lloris (c), Trippier, Alderweireld, Vertonghen, Davies; Dier, Mason (Carroll 72), Alli, Eriksen (Onomah 90+1), Son (Clinton 80); Kane. Substitutes (not used): Vorm, Wimmer, Townsend, Winks.
Goals: Spurs – Kane 78.
Yellow cards: Qarabag – Almeida 44, Garayev 88.
Referee: Tasos Sidiropoulos (GRE).