The team made an exit from the Carling Cup on penalties by a margin of 7-6 at Stoke after 120 minutes of football passed without a goal.
Jermain Defoe, Andros Townsend, Vedran Corluka, Younes Kaboul, Jake Livermore and Tom Carroll all netted past Thomas Sorensen, but Roman Pavlyuchenko could not take advantage of a miss by Jermain Pennant, with young midfielder Massimo Luongo, on for his debut in the second half, having what turned out to the the final kick saved by the Danish goalkeeper.
Harry Redknapp made nine changes for this third round tie at the Britannia Stadium.
Only Younes Kaboul and Benoit Assou-Ekotto survived from Sunday's win against Liverpool. Sandro made his return from a knee injury and Rafa van der Vaart started after returning from his hamstriong injury as a second half substitute on Sunday.
It was end to end and very open play in the first 10 minutes without either goalkeeper being called upon. In front of a fairly sparse crowd at the Britannia, there was little of the nip and tuck associated with the Premier League as the teams set about playing each other on the counter attack.
Central to this in our case was young Tom Carroll, given another opportunity, this time among more senior company than in his Europa League outings. The midfielder glided across the pitch, delivering crisp passes and always willing to accept possession.
The first half-chance of the game came from a set piece when a Matthew Etherington corner was headed over by Robert Huth, just after Kenwyne Jones fell victim to what appeared to be a hamstring injury, signalling the introduction of one Peter Crouch to a huge ovation from both home and away fans.
Stoke upped the tempo a notch as the clock ticked towards half-time with a barrage of balls launched into the area, with one chance nearly coming off a Crouch knock-down but Younes Kaboul was in place to block. The returning Sandro then forced Thomas Sorensen into his first work of the half with a shot from outside the area after a spell of possession.
Carroll attempted an unlikely but athletic volley from a Pavlyuchenko cross moments before the break but the deadlock in all honesty didn't look like being broken in the opening 45 minutes.
Jake Livermore curled narrowly wide on 48 minutes following a pass from Rafa van der Vaart. Pavlyuchenko then let rip with a drive that Sorensen needed two hands to palm over before Carroll took aim from the resulting corner, but wide of the top corner.
It was a period of enterprising, free-flowing football from the team in the ten minutes after half-time. The ball was being pinged around with great authority, with the home team chasing shadows.
Van der Vaart fired low and wide from a free-kick just outside the area after he was tripped by Robert Huth.
Heurelho Gomes did well with a double punch to deny Crouch a header on goal from a devilish cross from Etherington before Jermain Defoe was introduced in place of van der Vaart on 62 minutes.
Jermaine Pennant struck a free-kick from just outside the area that Sandro did well to plant a head on to divert away, just after Wilson Palacios made his exit and was replaced by Salif Diao.
On 70 minutes it was time for Sandro to call it a night in his comeback game and in place came Massimo Luongo, making his First Team debut.
It was Stoke cranking up the pressure as extra-timne neared without creating any clear cut openings. There was nearly one in the final minute when, from a whipped Pennant cross, Diao looked like applying a header, only for Kaboul to throw himself in the way right in front of goal.
Gomes was forced into a double stop a few minutes into extra-time, with Robert Huth slamming in a shot that bounced off the goalkeeper's chest and the rebound falling to Crouch. The goalkeeper was in place to foil and turn wide.
Harry's final card was then played, with Andros Townsend coming on for Giovani. Just before the first half of extra-time came to a conclusion came the best chance of the game. Etherington took a quick free-kick and played Jonathan Walters through to the right of the area. The striker pulled his shot just wide of the post.
Carroll shot across the face of goal after some neat interchange involving Vedran Corluka.
Extra-time, however, was lacking in major goalmouth incident. Much like the rest of the contest, the teams cancelled each other out and tiredness then came into play.
It appeared that the game would be settled by a spot-kick lottery. And so it was.
Stoke City (4-4-2): Sorensen; Shotton, Huth, Upson, Wilson; Pennant, Palacios (Diao, 66), Whelan, Etherington; Jones (Crouch, 12), Jerome (Walters, 74). Unused subs: Nash, Pugh, Delap, Wilkinson.
Spurs (4-5-1/4-4-3): Gomes; Corluka, Bassong, Kaboul, Assou-Ekotto; Giovani (Townsend, 95), Livermore, Sandro (Luongo, 71), Carroll, van der Vaart (Defoe, 63); Pavlyuchenko. Unused subs: Cudicini, Ceballos, Falque, Kane.
Penalty shoot-out details - Walters (1-0, Stoke), Defoe 1-1, Pennant miss 1-1, Pavlyuchenko miss 1-1, Whelan 2-1 Stoke, Townsend 2-2, Wilson 3-2, Corluka 3-3, Crouch 4-3, Kaboul 4-4, Etherington 5-4, Livermore 5-5, Upson 6-5, Carroll 6-6, Shotton 7-6, Luongo saved by Sorensen. Stoke win 7-6.
Referee: Mr L Probert.