'JD' will line-up alongside Liverpool's Peter Crouch in the friendly at Old Trafford, McClaren's first game in charge after taking over from Sven Goran Eriksson.
It will be Jermain's first start for England in almost a year - the last was against Denmark, a 4-1 defeat in Copenhagen on August 17, 2005.
Since then he's been used as a substitute three times and faced the agony of missing the final cut for the World Cup in the summer, the second major tournament he's just missed out on.
But there is a sense of new starts and Jermain has certainly been on song in pre-season with six goals, the latest a 20-yard cracker against Real Sociedad at the Lane on Saturday.
"Jermain has always impressed me, he's a confidence player and he likes to know where he stands," said McClaren on announcing his starting XI.
"He might feel he has something to prove and he has an opportunity tomorrow night to show what he is capable of.
"If we can get the ball to him in the right areas he can be very dangerous."
Steve McClaren spoke positively about Jermain Defoe after naming the striker in his first starting XI to face Greece tonight.