Having struggled for form since their 1-0 win over Liverpool in September, the hosts will be looking to put on a performance similar to those which they produced at the start of the season.
Spurs, meanwhile, are on an indifferent run, having won and lost alternately over the last five games, but Head Coach Mauricio Pochettino will be confident of leaving with the three points this weekend.
Favourites at 11/10, Spurs will also be aware that this has become somewhat of a bogey fixture for Villa – who have not triumphed in any match between the two sides since a 2-1 win in September, 2008.
As such, additional value can be found with Spurs to win by two goals at 51/10 or with a clean sheet at 11/4.
Harry Kane, who has been in good goalscoring form in the cup competitions, is 17/10 to score anytime.
Find more Aston Villa v Tottenham Hotspur odds at Marathonbet.co.uk