An impressive 3-1 win over Newcastle last week should ensure Spurs arrive on the south coast in form as they look to leapfrog Liverpool in the race for European football.
The Saints, meanwhile, have been winning and losing alternatively over recent weeks – with their victories coming against struggling Burnley and Hull.
A Christian Eriksen goal proved the difference when the two met earlier in the season and a repeat of that one-goal winning margin at the weekend is 22/5.
Additionally, the 14/5 available on a Spurs win is worthy of consideration alongside the 5/1 on offer for a win to nil.
Find more Southampton v Spurs odds at Marathonbet.co.uk