Spurs, meanwhile, who suffered a narrow 1-0 defeat to West Brom on Sunday, will be eager for a return to winning ways having now gone four games without a win after a promising start to the season.
Mauricio Pochettino will believe his players have what it takes as they seek to rediscover their winning formula and start as clear favourites at 63/100 to secure their passage into the next round.
Looking back, the sides last met in the 2004-05 FA Cup with Forest earning themselves a lucrative replay after a 1-1 draw at the Lane – a repeat of that scoreline after 90 minutes is currently 71/10.
Spurs won the return leg comfortably however, emerging 3-0 winners, and will believe they have more than enough to bring an end to Stuart Pearce’s unbeaten start to life at the City Ground.
At 37/10 to win by two goals, Spurs are also 11/5 to win to nil, although that could be considered a risk given that Forest have found the net in every game, bar one, this season.
So, with neither team scoring at the weekend, a first-half draw followed by a Spurs win is 69/20 with under 2.5 goals available at 33/25.
Find more Tottenham Hotspur v Nottingham Forest odds at Marathonbet.