The first leg will be at White Hart Lane on Thursday, February 14 with the away leg at Lyon's Stade de Gerland a week later on Thursday, February 21.
Lyon finished fourth in Ligue 1 last season and qualified for the last 32 by winning their group ahead of Sparta Prague.
If we manage to overcome Lyon, we will face either Inter Milan or Cluj in the Round of 16. Again, the first leg will be at the Lane scheduled for Thursday, March 7 with the second leg in Italy or Romania on Thursday, March 14.
Round of 32, draw in full...
BATE Borisov v Fenerbahce
Internazionale v CFR Cluj
Levante v Olympiakos
Zenit St Petersburg v Liverpool
Dynamo Kiev v Bordeaux
Bayer Leverkusen v Benfica
Newcastle v Metalist Kharkiv
Stuttgart v Genk
Atletico Madrid v Rubin Kazan
Ajax v Steaua Bucharest
Basel v Dnipro
Anzhi Makhachkala v Hannover
Sparta Prague v Chelsea
Borussia Moenchengladbach v Lazio
Tottenham Hotspur v Lyon
Napoli v Viktoria Plzen
Round of 16, draw in full...
Napoli/Plzen vs BATE/Fenerbahce
Bayer Leverkusen/Benfica vs Dynamo Kiev/Bordeaux
Anzhi Mackhachkala/Hannover 96 vs Newcastle/FC Metalist Kharkiv
VfB Stuttgart/Genk vs Borussia M'gladbach/Lazio
Tottenham/Lyon vs Inter Milan/CFR Cluj-Napoca
Levante/Olympiacos vs Atletico Madrid/Rubin Kazan
Basle/Dnipro vs Zenit St Petersburg/Liverpool
Ajax/Steaua Bucuresti vs Sparta Prague/Chelsea