Kyle Naughton experienced a memorable return to his former home as Leicester City triumphed at Sheffield United in the Championship.
And Adam Smith was part of the Bournemouth side that came out on top in a 3-2 thriller with Swindon in League One.
But the pair were the only Spurs players on loan to experience success in Tuesday night’s fixtures.
Andros Townsend had a hand in both goals as Watford were held 1-1 at home to struggling Crystal Palace in the Championship.
The winger got the better of his full-back to set up the opener for Andreas Weimann before being dispossessed by Wilfried Zaha who set up James Vaughan for the equaliser later in the first half.
Andros could have made up for that when his free-kick appeared to strike a defender’s hand in the box on the hour mark, but no penalty was awarded.
David Button made a key early save from Dean Bowditch but could not prevent Plymouth slipping to a third straight defeat at Yeovil in League One.
Kyle Walker got his first taste of football at Old Trafford but Aston Villa were on the wrong end of a 3-1 Premier League defeat against leaders Manchester United.
Steven Caulker is without a win in six games now as Bristol City were once again defeated, this time by two goals to nil at home to Swansea.
And Paul-Jose M’Poku could not make an impact after coming off the bench on the hour mark in Leyton Orient’s 0-0 home draw with leaders Brighton in League One.
Harry Kane and Tom Carroll were unused substitutes for the O’s in that game, as was Ryan Mason for Doncaster in their 1-0 home win over Burnley in the Championship.
Our more senior on-loan players, David Bentley (Birmingham), Robbie Keane (West Ham) and Jamie O'Hara (Wolves), are all set to be in Premier League action on Wednesday night.