Belgian international goalkeeper Mignolet has been on the bench since September 16 with Loris Karius taking over in goal while striker Ings, out with a serious knee injury for most of last season, has only appeared in the Reds' EFL Cup wins at Burton and Derby so far.
Klopp told media at his pre-match conference: "The chance (Mignolet will play) is at 100 per cent - it’s a good chance! That’s only if nothing happens in training, then he will play 100 per cent."
Jordan Henderson is suspended and Klopp has no fresh injury concerns. “There’s nothing really serious, a few knocks. A few boys didn’t train yesterday, but the (West Brom) line-up didn’t train, they had recovery and were in therapy. There has been nothing serious until now, so hopefully it stays like this."
Below: Dele Alli takes on Adam Lallana at the Lane in August
Having drawn 1-1 in the Premier League in August, Klopp expects a close encounter in the fourth round of a competition Liverpool have won more times than any other club - and were runners-up in last year, losing out to Manchester City on penalties in the final.
Speaking on Spurs, Klopp said: "They are still good. Good in defending, good in attacking, not a lot of weaknesses. It will be close but that's no problem, it makes it exciting."
Meanwhile, Klopp is leaning on the Anfield crowd to make a difference.
"It’s again, what I said after the (West Brom) game about the atmosphere, I think everybody who was there thought something was different today.
"We are not four, five, six nil in the lead but the atmosphere was really fantastic and that’s what we have to try to create again.
"All the other teams will make as many problems for us as possible but being really in the game as a team and a crowd that’s the thing we can still improve.
"Creating a real Liverpool atmosphere more often, or always, that’s the challenge for all of us. I'm really looking forward to the game.
"It's another game at Anfield, it is still fantastic to play there, and against a strong opponent it's the best thing you could wish."