Goals from Luis Suarez and Jordan Henderson gave the Reds a 2-0 half-time advantage.
And following the dismissal of Paulinho, the visitors went on to add further goals through Jon Flanagan, Suarez and Raheem Sterling.
Spurs (4-2-3-1): Lloris, Walker, Capoue, Dawson, Naughton (Fryers 46), Sandro (Holtby 30), Dembele (Townsend 60), Lennon, Paulinho, Chadli, Soldado. Substitutes (not used): Friedel, Lamela, Defoe, Sigurdsson.
Liverpool (4-2-3-1): Mignolet, Johnson, Skrtel, Sakho, Flanagan, Allen, Lucas (Alberto 78), Henderson, Sterling, Coutinho (Moses 89), Suarez. Substitutes (not used): Jones, Toure, Agger, Aspas, Kelly.
Goals: Liverpool – Suarez 18, 84; Henderson 40; Flanagan 75, Sterling 89.
Yellow cards: Spurs – Dawson 27, Walker 43, Holtby 66.
Red card: Spurs – Paulinho 63.
Referee: Mr J Moss.