It all started back in season 1991-92 when QPR stunned United and a live television audience with a 4-1 victory at Old Trafford - Les was at the club but didn't play that game.
He then scored in successive home games against United for QPR in 1993-94 and 1994-95 including what he describes as the best goal of his career, a thunderbolt into the top corner from 25 yards that left the great Peter Schmeichel grasping at thin air.
Onto Newcastle and Les scored again in the famous 5-0 drubbing of the champions in 1996-97 only for United to hold off Kevin Keegan's men and hold onto teh title.
He has continued to enjoy relative success at Spurs - giving Sir Alex Ferguson's men palpatations with an opening goal as they went for the title on the last day in 1998 (United won 2-1 and lifted the crown again) and, just back in May, he cracked another fine effort in our 3-1 win at the Lane.
Les recalled: "I didn't play in the 4-1 win but we good decent results against United at QPR - and not so good. I've always managed to nick a goal or two against them so let's hope the same happens again on Saturday.
"It's one of those games everyone looks forward to, players as much as supporters. In recent years we've done pretty well against United but it's important we don't get carried away with that and give a good, professional account of ourselves.
"Everyone wants to do well against United and there is always so much hype that goes with playing them. I'm not saying other games aren't the same but there is that extra special feeling against them."
Like Glenn Hoddle, Les doesn't buy into the 'poor start' and 'good time to play them' theories being talked about the Old Trafford giants.
He added: "People are talking about them perhaps not starting the season as well as they wanted to. We've seen them blast off at the start of seasons and we've also seen them start of like this and finish strong.
"They have quality in their side and it won't be long before that quality comes through but hopefully it won't be against us on Saturday."
Les Ferdinand is ready to do battle with Manchester United again on Saturday - and few strikers have enjoyed as many good times as Sir Les against the champions.