The England star lined-up alongside Ben Thatcher in another new central pairing in a 4-4-2 system against Liverpool on Sunday.
We've fielded various permutations of both 4-4-2 and 3-5-2 systems but only one thing has remained constant - injuries forcing change.
"I've lost count of the different partnerships," said Ledley. "I've played with Ben a few times and most times it's when he's come in. This time we had a bit longer to train together, work together and that helped.
"But there have been quite a few injuries and it's been disappointing."
Ledley was outstanding and the Reds feared strikeforce of Michael Owen and Emile Heskey rarely opened us up defensively in the 3-2 defeat - Liverpool's first two goals came via our mistakes, the third on the break.
"These are the games you've got to want to play," added Ledley, who stated last week that he was up for the challenge. "There is no-one better than Michael Owen and I relished the chance to take him on.
"They are in form but I thought we started well and could have been ahead at the break.
"Having said that we still managed to take the lead but couldn't hold onto it long enough to get any momentum going.
"I thought the goals went against the run of play. They have pace in the team and punished us three times, clinically."
Ledley King summed up our luck on the injury front by admitting he'd lost count of our various defensive combinations this season.