Our captain and central defender had to withdraw from England's friendly against Holland this week because of continuing groin problems.
Head Coach Martin Jol explained this afternoon: "We can push him but he's been complaining about the pain for the last couple of weeks. He could do with a rest, that's for sure.
"We are working on it. He's doing different programmes in the gym with the medical staff. He's played all the matches and you tend to get little muscular injuries."
Martin had some sympathy for Ledley as it looked almost certain he would have started at Villa Park with Rio Ferdinand, Sol Campbell and John Terry all missing.
"I'm sure it was disappointing for him," added Martin. "It was his chance to show what he could do. He's been outstanding this season, our best player.
"It's a bit unfortunate with the likes of Terry, Campbell and Ferdinand but I feel he's in the same bracket and he's a bit younger. It was his chance but I think they were sensible to pull him out."
Ledley King is a doubt for Saturday's FA Cup fourth round replay against West Brom.