The skipper picked up an ankle injury in training on Friday and it was decided not to risk him at St James Park.
Head Coach Martin reported: "Ledley took a knock in training on Friday and twisted his ankle and had a little problem in his knee as well because of the twist.
"Maybe I could have played him but we were worried about it so we decided to give him a rest because it could have made it worse for the rest of the season.
"Hopefully one of the positives will be that he can now play next week because we all know how important he is to us."
We take on City at the Lane on Saturday, kick-off 12.45pm.
Martin Jol is hopeful Ledley King will be fit to face Manchester City next week after he missed Saturday's defeat at Newcastle.