In what was possibly our most entertaining game on the road in December, goals from Chris Perry, Simon Davies and Gus Poyet won the night after City had taken the lead through Steve Howey and replied with a final minute goal from Ali Bernarbia.
City have won only one of their last eight, but Kevin Keegan's side are committed to attack and Ledley suspects that home advantage could be the crucial factor.
"They are a funny team to play against," he said. "We are confident at home though and we definitely see three points there.
"It was a spirited performances up there and if we can show the same kind of qualities I'm sure we can get the points," added the central defender, who feels our back line will have to be on their guard to cope with the potentially dangerous strikeforce of Robbie Fowler and Nicolas Anelka.
"They've both got their qualities and are two completely different type of players - I'm sure they are going to be a handful."
Meanwhile, Simon Davies believes that two victories over the Easter period would make for a 'interesting' climax to the season.
"We've a couple of games coming up in quick succession and they are games now that we feel we can win.
"If we can get six points from them it will make things interesting."
Ledley King reasons that a repeat of the 'spirited performance' at Maine Road should see the points added to our tally after the clash with Manchester City on Friday.