Spurs convincingly beat the East London side 5-0 last week to reach the Ryman Cup Final before racing into a 4-0 lead and eventually beating Swindon Town 4-1 in the second round of FA Women's Cup on Sunday.
Now it's the Hammers again on Sunday, this time in the quarter-final of the Capital Cup - a competition run between the London FA, Middlesex FA and AFA (Amateur Football Association) - and manager Karen Hills is taking nothing for granted.
"I'm sure we'll get a reaction from West Ham after the Ryman Cup semi-final," said Karen. "It's at their place this time and they won't want a repeat of that result.
"So we know it will be tough and it's up to us to go out there and make sure we do things right."
If Spurs manage to beat West Ham, they will face Camden Town in the semi-finals.
WOMEN'S FA CUP - SWINDON TOWN 1-4 SPURS LADIES
Spurs did the damage in the first half of last Sunday's second round tie.
Leah Rawle gave the team the perfect start by glancing home a header from Bianca Baptiste's free-kick, it was soon 2-0 via an own goal, Rawle's cross then found the far corner of the net for 3-0 and it was 4-0 by half-time when Lucia Leon's pass released Avilla Bergin to finish in style.
"I will say we had a little luck with two of the goals but it was important to start well and we did just that," said Karen.
"The positive thing was to see Ronnell Humes start again and Jonea Peters come off the bench for her debut.
"We had a number of players out including the likes of Wendy Martin, Shannon Moloney, Lucy Loomes, Megan Wynne, Mia Vio and Katie O'Leary so to see these players step up is great news for the squad."
Spurs Ladies v Swindon Town: Toni-Anne Wayne, Sophie McLean, Alex Keown, Jenna Schillaci, Leah Rawle, Lucia Leon, Ria Soobadoo, Ronnell Humes (Kellie Blanchflower 55), Rosie Kmita, Bianca Baptiste (Jonea Peters 70), Avilla Bergin.
The win sees Spurs travel to Gillingham in round three on Sunday, February 7.
Below: Karen speaks to Your Sport Swindon after last week's FA Cup win
RYMAN CUP FINAL
Spurs Ladies will play Charlton in the final of the Ryman Cup after Charlton beat Herne Bay 9-0 in their semi-final this week. It's a repeat of last season's final and provisionally scheduled for April 14.
GEMMA INTO WALES UNDER-16 SQUAD
Congratulations to Gemma Biggadike, who has been called into the Wales Under-16 squad for a three-day training camp on February 2.
Karen added: "It's yet more fantastic news and great reward for the work we have been doing at youth level. We are really seeing the benefits of our player development objectives."