They take on title-chasing Cardiff at Ware FC (2pm) in their final match of the FA Women's Premier League South campaign.
It's been another season of progress for the ladies, who were sucked into a relegation battle last season but are clear of trouble this time around and have seen youngsters like Danni Albertsen, Lucia Leon, Rene Williams and Maya Vio all taste first team football.
"It's a tough game to finish the season but we're determined to put in a good performance and then look to build again next season," said manager Karen Hills.
The team lost out to a late goal against Keynsham last time out.
Aimee Clark opened the scoring for the Somerset-based team five minutes before half-time, Davina Smith headed home the equaliser but Rafaela Silva grabbed the winner in the 85th minute.
Spurs were without injured regulars Wendy Martin, Bianca Baptiste and Jenna Schillaci as Ellana Moseley, Shakira Waithe and Shona Chitate-Samuriwo all featured.
"It was great experience for those girls," added Karen. "Ellana has played for both first team and reserves this season, she's quick and puts herself about on the pitch.
"It was Shona's first team debut and Shakira has come up through our college team (the Foundation's Education and Football Development Centre at Barnet and Southgate College) and she's played for us at all levels this season, development team, reserves and now first team.
"As for the game itself, it was always going to be a difficult task for us without some key players and with Keynsham needing points. We did well, missed chances and then paid the price."
Spurs Ladies v Keynsham: Chloe Morgan; Danni Albertsen, Amy Cooper, Fran Gamble, Lucia Leon, Shannon Maloney, Andra Marcoci, Ellana Moseley (Shona Chitate-Samuriwo, 85), Sophie McLean (Shakira Waithe, 78), Derrie O'Halloran, Davina Smith. Unused sub: Courtney Miller.