Steven Caulker, Jermain Defoe, Scott Parker and Kyle Walker are with the England squad in Montenegro for a huge match in Group H.
Both teams are unbeaten. Montenegro currently top the group by two points with four wins and a draw in five matches. England have drawn twice, against Ukraine and Poland.
Victory for the home side will take them five points clear, victory for the Three Lions will see them back on top of the group with the return match at Wembley to follow.
Hugo Lloris should captain France in the game of the night as they take on reigning World and European champions Spain at the Stade de France.
Spain were surprisingly held at home by Finland on Friday and having already drawn in Madrid, France can move five points clear in Group I with victory.
Staying in Europe and Spurs interest in Group A, where Mousa Dembele and Jan Vertonghen will be hoping for a favour from Gareth Bale and Wales.
Mousa and Jan top the table with Belgium and face Macedonia in Brussels, just a few days after beating the same team in Skopje.
Belgium have an indentical record to Croatia - four wins and a draw - and top the group on goal difference. Croatia, meanwhile, travel to Swansea to take on Wales.
Away from Europe, Clint Dempsey is preparing for the big one as far as the USA is concerned when they travel to the famous Azteca Stadium to take on Mexico in the North/Central America and Caribbean zone.
Clint will captain the USA having scored the winner in Friday's 1-0 win against Costa Rica in Denver.
USA are currently second in the final phase of qualifying with six teams vying for three automatic places in the finals in Brazil.