'JD' netted twice in the 5-0 victory in a completely one-sided game at Old Trafford - Paul Robinson barely had a touch in the England goal.
Involved in the first goal, Jermain struck a sweet third after 38 minutes from Steven Gerrard's inviting cross. That was his first goal for England since notching against Poland in September, 2004.
Peter Crouch and Gerrard were also on target as England made it 3-0 at half-time.
Jermain was on the spot again four minutes into the second half to make it 4-0, latching onto Phil Neville's header, rounding Koldo in the Andorra goal and slotting home. He was denied a hat-trick soon after by Koldo.
The Spurs theme continued after 65 minutes when Aaron Lennon, only just on as substitute, beat his man and crossed for Crouch to head home the fifth.
Elsewhere, it was a mixed day for our international players in European Championship qualifying action.
Teemu Tainio's Finland made a dream start to their campaign with a 3-1 win in Poland - Teemu came close to scoring in the first half and played the full 90 minutes.
Robbie Keane had the misfortune of deflecting Lukas Podolski's free-kick past Shay Given for the only goal of the game as the Republic of Ireland lost 1-0 to Germany in Stuttgart.
Dimitar Berbatov was substituted after 62 minutes as Bulgaria fought back from 2-0 down to grab a 2-2 draw in Romania while Marton Fulop was an unused substitute as Hungary lost 4-1 at home to Norway.
Jermain Defoe was back amongst the goals as England cruised past Andorra in their opening Euro 2008 qualifier on Saturday.