United will be desperate to get back on the Premiership points trail after successive defeats, but Jamie says the boys should have the confidence to go there and play their own game.
"They are big games," reasoned Jamie. "You go to Old Trafford and it's a great stadium and a great team so you know it's going to be a very, very tough game.
"The thing is, we're going there on the back of a win. That is important, you need to go there with confidence, which we should have at the moment.
"They are going to be desperate to win because they have lost two on the spin in the Premiership. That doesn't happen very often to Manchester United as they are a special team.
"But it is important that we go there, play well and don't play with any fear."
Jamie adds that, like ourselves, United have suffered with multiple injuries, particularly in one area of the team. United have also been hit hard in midfield and have been without Paul Scholes, Roy Keane, Nicky Butt and Juan Veron in recent games.
"They've got a lot of injuries, pretty similar to us, and they've got a couple of long-term ones which is obviously not very helpful."
Whatever line-ups both teams field, Jamie agrees that to emerge from Old Trafford with any sort of positive result would be a major achievement.
"Of course, that is the important thing. You know what to expect there, they are a great team who pass the ball well - you can't knock Manchester United.
"It is just important that we try and match them, go there and enjoy it and don't play with any fear."
Jamie Redknapp insists Spurs must not play with any fear when they step out at Old Trafford to play Manchester United today.