Jan Vertonghen captained the Belgium team and played 90 minutes, Nacer Chadli played 62 minutes but Mousa Dembele and Ben remained on the bench as it finished goalless in Brussels.
Nacer had one of the best chances in the first half when he was played in by Divock Origi on the left side of the box and held off Ashley Williams only for Wales goalkeeper Wayne Hennessey to rush off his line to block.
Belgium also hit the post through Nicolas Lombaerts and Hennessey denied Christian Benteke in the final seconds of injury time. Gareth Bale went closest for Wales, his free-kick saved by Thibaut Courtous in the first half before flashing a shot just wide after the break.
The draw leaves Wales second in Group B with Belgium fourth and Israel the new leaders after beating Bosnia-Herzgovina 3-0.
It's all about our young internationals on Monday.
We have six players on duty for England with Harry Kane, Tom Carroll and Alex Pritchard in the Under-21 squad for the friendly against France in Brest, Kyle Walker-Peters and Josh Onomah with the Under-18s for a friendly against Poland in Gdansk and Dominic Ball with the Under-20s for a friendly against Portugal in Coimbra.
Meanwhile, Kenny McEvoy is in the Republic of Ireland Under-21 squad for a friendly against Russia in Marbella.