Gareth Southgate revealed his decision last night, with Harry becoming the ninth Spurs player to lead the Three Lions.
England top Group F of World Cup qualifying. Dele Alli, Eric Dier and Kyle Walker are all tipped to start. Kieran Trippier is also in the squad.
Southgate said: "We have several players who have excellent leadership qualities and Harry is a player we have worked with, with the Under-21s before.
"He’s got a terrific mentality and I know he is delighted to be leading the team.
“He finished the season in great form and any team would want a finisher of his quality in their side.”
Below: Toby in action for Belgium against Estonia on Friday night
FRIDAY'S WORLD CUP QUALIFYING ACTION
Toby Alderweireld and Jan Vertonghen played the full 90 on a good night for Belgium in WCQ Group H.
Goals from Dries Mertens and ex-Spur Nacer Chadli saw Belgium home 2-0 in Estonia and with Bosnia & Herzegovina and Greece drawing, Belgium moved four points clear.
Vincent Janssen made it three goals in three post-season internationals as Holland hammered Luxembourg 5-0 in Group A, firing home from the penalty spot for the final goal after being upended himself in the box.
Holland are still chasing down France and Sweden in Group A but the standings closed up last night as Sweden beat France in dramatic late style in Stockholm.
Hugo Lloris captained the French team again with team-mate Moussa Sissoko also in Les Bleus' line-up.
Olivier Giroud opened the scoring for France, Jimmy Durmaz levelled before half-time and Sweden snatched it in added time when Hugo's clearance fell to Ola Toivonen, who drilled back home from 50 yards.
France and Sweden are now joint-top on 13 points with Holland third on 10. Only group winners goes through to Russia next summer with the eight runners-up into play-offs.
As well as our five Englnad players in Scotland, Christian Eriksen is in WCQ action for Denmark in Kazakhstan on Saturday evening.
Victor Wanyama (for Kenya in Sierra Leone) and Christian Maghoma (for DR Congo against Cameroon) are in African Cup of Nations qualifying action.
Meanwhile, Japhet Tanganga is in the England U20 squad for the final of the Toulon Tournament against Japan.