England were in the driving seat early in Cork with goals from West Ham's Mark Noble (2) and Newcastle's James Milner. It was 3-0 at half-time and stayed that way.
It means England have kicked off Group Three with four wins out of four.
Younes Kaboul also played 90 minutes and captained the French U21 in a goalless draw in Romania. France also top their group with 11 points from five games, Romania are second.
Paul Robinson and Jermain Defoe travel to Moscow to face Russia with England and an encounter with Sparktak Moscow's artificial surface. Kick-off 4pm.
Gareth Bale's Wales travel to San Marino, Robbie Keane's Republic of Ireland face Cyprus at home and Dimitar Berbatov's Bulgaria are in Albania.
Elsewhere, Didier Zokora is with the Ivory Coast for a friendly against Austria and Tomas Pekhart faces Armenia at home with Czech Under-21s.
Thousands of people have already given their support to the Club’s plans for a new Football Training Centre in Enfield but the Club is calling for anyone who supports the scheme and who hasn’t submitted their details to clickHEREand make their voice heard.
Tom Huddlestone played 90 minutes as England maintained their perfect start in European U21 Championship qualifying against the Republic of Ireland on Tuesday night.