It starts tonight with Dean Marney hoping to make his England Under-21 debut against Holland at Derby's Pride Park, Stephen Kelly and Mark Yeates on Under-21 duty for the Republic of Ireland against Portugal and Marton Fulop in Cyprus with Hungary Under-21s.
On Wednesday, Jermain Defoe and Paul Robinson look to add to their England caps in the friendly against Holland at Aston Villa although Ledley King, who looked set to start, has pulled out with a groin injury.
Robbie and Andy Reid are with the Republic of Ireland for the friendly against Portugal at Lansdowne Road, Simon Davies returns to the international fold with Wales against Hungary and Erik Edman faces France with Sweden.
Further afield, Noureddine Naybet has an important World Cup qualifier for Morocco against Kenya while Thimothee Atouba has a friendly for Cameroon against Senegal and Fredi Kanoute travels to Guinea Conakry with Mali.
We have 13 players on international duty this week - here's the run down...