Paul Robinson and Jermain Defoe look set to start for England against Andorra at Old Trafford (5pm) where Michael Dawson could make his debut for the injured Rio Ferdinand. Aaron Lennon and Jermaine Jenas make up the Spurs five in the squad.
Robbie Keane will lead the Republic of Ireland out in an eye-catching clash at World Cup hosts and beaten semi-finalists Germany (7.45pm) in Stuttgart.
Teemu Tainio's Finland face a tough start in Poland (7.30pm), Dimitar Berbatov's Bulgaria travel to rivals Romania and Marton Fulop is in the Hungary squad taking on Norwayn (both 7pm).
In Friday night's action, Reto Ziegler's Switzerland set up an all-or-nothing encounter against England on Wednesday after beating Moldova in their European U21 Championship qualifier.
Reto was involved in the move for the second goal as the Swiss won 3-1. Switzerland and England - who drew with Moldova - now meet in Luzern on Wednesday and the winners will go through to the play-offs.
Meanwhile, Terry Dixon was a late substitute as the Republic of Ireland U21s lost 1-0 at home to Belgium.
Nine of our players representing five countries kick-off their European Championship qualifying campaigns on Saturday.