Former Spurs midfielder Jake Livermore fired the hosts into a first half lead, before seeing his side reduced to 10 men after the break when Gaston Ramirez saw red following an off-the-ball incident with Jan Vertonghen.
We equalised just after the hour mark when Harry Kane reacted quickest to slide home after Christian Eriksen's free-kick came back off the frame of the goal, before the latter popped up with a low shot to win the game in the 90th minute.
Hull (4-5-1): McGregor, Robertson, Dawson, Davies, Elmohamady, Ramirez, Livermore, Huddlestone (Rosenior 64), Ben Arfa (Meyler 57), Brady (Quinn, 87), Jelavic. Substitutes (not used): Harper, Chester, Hernandez, Sagbo.
Spurs (4-2-3-1): Lloris, Dier (Chiriches 46), Fazio, Vertonghen, Davies, Mason, Dembele (Lennon 59), Eriksen, Kane, Lamela, Soldado (Paulinho 79). Substitutes (not used): Vorm, Ball, Stambouli, Ceballos.
Goals: Hull – Livermore 8; Spurs – Kane 61, Eriksen 90.
Yellow cards: Hull - Livermore, Huddlestone, Quinn. Spurs – Dier.
Red card: Hull – Ramirez.
Referee: Craig Pawson.