The striker has racked up 19 goals in 27 capital clashes in the Premier League including registering in five north London derbies on the trot.
Those derby goals contributed to his total of 29 to win the Premier League's Golden Boot for the second-successive season and 35 in all competitions in 2016-17.
Now he's targeting the 'Auld Enemy' alongside Dele Alli, Eric Dier, Kieran Trippier and Kyle Walker as the oldest match on the international calendar - indeed, the first-ever international first played in 1872 - returns to the football spotlight.
Below: Harry training with England this week
Asked if the match was still a 'big deal', Harry responded: "I still think it means something. It is like maybe playing for your club in derbies, it’s the same sort of feeling.
"We definitely know how much it means to everyone and it means a lot to us as well.
"We were all England fans growing up and we all know what it meant and just because we play for the team, it doesn’t mean that has changed. It is important that we go out there with that mindset.
"We know it is going to be a very passionate game and we hope we are going to send our fans home happy."
England won the corresponding fixture 3-0 at Wembley in November - Eric, Kyle and Danny Rose all started - and the Three Lions top Group F with four wins and a draw from five matches so far. Only the group winners go directly to the finals in Russia in 2018 with eight runners-up chasing the final four places in play-offs. Scotland are six points behind England but only two adrift of Slovakia currently in second.
Harry didn't feature in the Wembley game as he recovered from injury and won the last of his 17 caps in September.
"It feels like ages since I last played a game (for England), so I am looking forward to it," he added. "I would love to score on Saturday and get back out there and get that feeling again.
"It is going to be a tough game. Everyone knows the atmosphere is going to be fantastic. Scotland will be trying to reduce the gap in the group, but we are a confident team. Away from home, it is going to be difficult, but we've just got to play in our style and try to win the game."