The Welsh dynamo was dismissed for two yellow cards but replays showed that he made no contact with Ashley Cole for the first booking and even the second, after a 50-50 challenge with Patrick Vieira, was deemed harsh by the boss.
But the midfielder had to depart after just 26 minutes and with us already trailing 1-0, the decision turned an uphill task into a mountainous one.
Glenn said: "We're very disappointed. I think the referee has to have a look at it and change his view on it.
"Simon hasn't made any contact at all and I'm not saying Ashley did anything wrong, I've watched it back myself, but certainly on video it shows that no contact was made and it's cost us.
"I think Ashley may have thought the tackle was coming in. Simon is scratching his head, like everyone else is, as to why on earth he's been booked. There were full-blooded tackles going in and to get booked for that, well, we might as well pack the game in. In the heat of the moment the referee might have thought something was worse than it was.
"Even the second yellow is a 50-50 tackle which both of them had a bit of the ball and even that one is debatable.
"We'll have a word with the referee and hopefully common sense will prevail.
"Before we leave I'll go in there, make sure he has a look at it and see if we can get it turned over. It deserves to get turned over. Sometimes you can't defend players, late tackles, I would never do that, but sometimes it's only right that you stand your ground if you believe there has been an injustice."
Glenn Hoddle will appeal against Mike Riley's decision to send off Simon Davies in Saturday's derby at Highbury.