The tie will take place at Craven Cottage in the week commencing November 26. Fulham beat Derby County 5-2 under the watchful eye of Glenn Hoddle in the third round on Wednesday after we'd beaten Tranmere Rovers 4-0 on Tuesday.
Other highlights in the last 16 include Leeds hosting Chelsea while Grimsby Town's reward for their shock win at holders Liverpool is an away tie at either Arsenal or Manchester United.
The full draw is as follows:
Leeds United v Chelsea
Aston Villa v Sheffield Wednesday
Fulham v Spurs
Blackburn v Manchester City
Arsenal/Manchester United v Grimsby
Bolton v Southampton
Watford v Charlton
Newcastle v Ipswich
Ties played week commencing November 26.
We've been drawn away at Premiership rivals Fulham in the fourth round of the Worthington Cup.