The French international midfielder was forced off during the second half of Saturday’s 2-1 victory at Middlesbrough and Mauricio Pochettino has confirmed that he will play no part in Russia.
"Moussa Sissoko got a head injury in the game against Middlesbrough and he is out,” he confirmed. “We can’t rule out concussion and so we are treating it this way."
Mauricio also confirmed that Danny Rose, Eric Dier, Mousa Dembele and Harry Kane remain sidelined and have not travelled as they continue recovering from their respective injuries.
Kick-off on Tuesday night is at 9.45pm local time, 7.45pm UK.
Advice for fans travelling to Moscow...