The flying full-back picked up a fifth yellow card of the Premier League campaign against West Ham last weekend and has to sit it out against Chelsea.
Mauricio Pochettino is therefore without both regular left-backs with Ben Davies (ankle) injured. Toby Alderweireld (leg) and Erik Lamela (hip) remain sidelined.
"Danny Rose is suspended, Erik Lamela, Ben Davies and Toby Alderweireld are still out for Saturday," confirmed Mauricio after training on Thursday.
A reminder that we kick-off at 5.30pm.