The Hornets have beaten Sunderland (1-0) and West Bromwich Albion (2-0) at home over the last week.
Reports coming out of Vicarage Road suggest that Mazzarri’s options may be limited at the Lane, with a raft of players potentially unavailable through injuries and suspensions.
However, Mazzarri, who was also forced to field a depleted side against us in the reverse fixture on New Year's Day, which we won 4-1, wants those who take to the pitch to stake a claim for a regular place in his team.
“It’s our destiny,” he said. “Against Tottenham, we are always in an emergency.
“We had one of the best games since I’ve been here on Tuesday (against West Brom), we played the game the way I like and I would’ve liked to have been able to play against Tottenham with a full team.
“But I told my players (on Thursday) morning that whoever is going to play Saturday has the chance to show that they deserve to have been playing in the past as well.”
Asked how he sees us in the title race, Mazzarri commented: “Chelsea have the advantage, but there are eight games left and Tottenham have proved to be really good. They at least deserve second place.”
On his own team’s ambitions for the rest of the campaign, he added: “First we must be mathematically safe. Of course our target is to remain in the Premier League, but I always tell my players to never be satisfied.
“There are no limits for me. We must play every match as a final. We’ve got 24 points to play for and we want to go as high as possible for two reasons. First it is a question of having a winning mentality, and we will also see for next season who deserves to stay in the squad.
“Now that we have reached 37 points and we are eight games from the end of the season, my players can play more freely. They can be calmer and they have more room to play.”