The equivalent fixture in 2015-16 represented the German's first game in charge of the Reds and yielded a 0-0 scoreline – the first of two draws between the sides over the course of the campaign.
Ahead of this weekend's match, Klopp – who guided the Reds to a 5-0 EFL Cup win over Burton Albion in midweek – has been speaking about the influence of certain players and has underlined how he believes the game represents a different challenge to those which Liverpool have faced against Arsenal (4-3 victory) and Burnley (2-0 defeat) so far this Premier League season.
"Tottenham are absolutely convinced about their way and their style of play," he said at his pre-match press conference.
"They didn't change too much and they have high individual quality. They can even leave Alli out, that's a big difference from last year and with Janssen they have a really skilled striker. Harry (Kane) can play from a number 10 position too and did it well (against Crystal Palace last week).
"Wanyama and Dier in the centre is a little bit different to Dier and Dembele. The rest of the team is very experienced and has played together one-and-a-half or two years nearly, but they are still young so there's still space for development.
"This game can be completely different to the last two games we played. The whole situation on the pitch will be different. They are a pressing team, a high-pressure team, so we need to know about this. They don't give away a lot of spaces but there are spaces, of course.
"We know they are strong, that's the only thing we need to know. We can be strong too.”