The former Watford boss and Chelsea midfielder has already seen his team scalp Premier League opponents in the competition this season after a 4-1 triumph over Hull City in round four.
As we prepare to travel to Craven Cottage in the last 16, the manager of the eighth-placed Championship outfit has been speaking about his team's determination to see off another higher-ranked side.
“We're motivated by the opportunity to play a strong team like Tottenham in the FA Cup,” he said.
“This competition is famous for its surprises. It's a fantastic chance for us and isn't a moment for us to surrender.
“I will choose the best XI for the game in front of us. It's one of the top Premier League teams and (this) isn't a time to experiment.
“It's a great opportunity, for myself, Fulham, my players and the fans. We don't need any further motivation.”
One man Jokanović won't be able to call upon is former Spur Ryan Fredericks, who is suspended for the game.
“The other players are available,” he added. “Tomas Kalas worked with us today and is available.
“I believe Spurs will rest some players. They won't experiment but (Mauricio) Pochettino has a quality squad.”