It ended goalless in Klopp's debut back in October and the spoils were shared again at Anfield in April.
Now the Reds have a new-look line-up with summer arrivals Ragnar Klavan, Georginio Wijnaldum and Sadio Mane featuring so far and Joel Matip expected to come in for his Premier League debut in the 12.30pm kick-off.
"Liverpool have signed a lot of players and I’m sure it will be a different team to last season," said Mauricio. "We will analyse and try to find the information to beat them.
"It will be a very tough game against a very good team. Liverpool will be one of the tougher teams to play against but all the games in the Premier League are tough and all opponents are difficult."
Below: Mauricio talks Champions League and Liverpool
On knowing Clyne, Lallana and Lovren
Mauricio: "I know a lot of players but when you play, during the game you are enemies and we try to do the best for our team."
On last week's win against Palace
Mauricio: "It was good for us, our confidence and self-belief. It was important. We try to improve every day and now is an opportunity to show our skills against one of the best teams in England."
On Kane and Janssen v Palace
Mauricio: "It was a good opportunity to see Vincent and Harry play together. The good thing is that we have different alternatives and the starting 11 will be a team that can win this game."
On team news
Mauricio: "Mousa Dembele is still suspended, Hugo Lloris (hamstring) is going well but he's still out."
Read more from Mauricio in Saturday's official matchday programme - 100 pages, £3.50.
- Feature interview with new signing and last week's match winner, Victor Wanyama
- Discussing Michel Vorm's attributes in 'Centre of Attention'
- Reflecting on past encounters with Liverpool and a look at their current squad
- Interview with Norwegian author and Spurs fan Jo Nesbø
- Second instalment of ‘The White Hart Lane Years’
Sample it now with our FREE online 12-page preview edition.
You can also purchase the full 100-page online edition here.