The Manchester United manager spoke to the media ahead of Saturday lunchtime's clash between two sides level on 20 points in the Premier League's top three.
Asked about facing us in the wake of our slip-up against West Ham in the Carabao Cup in midweek, Mourinho speculated: "My feeling is that the majority of the players that played that match are not going to play tomorrow.
"I may be wrong. Sanchez, Vertonghen, Eriksen, Aurier, Winks (were) not involved in the game or they played just a few minutes. So, I don't think it (the West Ham result) will impact (Saturday's game)."
Mourinho continued: "They are a young and fit side, especially physically, and I think they will be a very strong team.
"I just think normally we have performances at home, normally we trust our game and, yes, the results (have been) positive at home. We had lots of draws at home last season – too many – but normally at home we are a strong and confident team. So, we will try to do the same tomorrow."