The visitors' highly-rated marksman Pierre-Emerick Aubameyang scored either side of half-time to put Dortmund 5-0 up overall following last week's 3-0 reverse in Germany.
Heung-Min Son capitalised on a defensive mistake to pull a goal back 17 minutes from time but the tie was beyond us by then and we bowed out of the competition 5-1 on aggregate.
Spurs (4-2-3-1): Lloris (c), Trippier, Alderweireld, Wimmer, Davies (Rose 13), Dier, Mason, Lamela (Onomah 74), Alli (Carroll 69), Chadli, Son. Substitutes (not used): Vorm, Carter-Vickers, Winks, Kane.
Borussia Dortmund (4-2-3-1): Weidenfeller, Piszczek, Subotic, Papastathopoulos (Durm 54), Schmelzer, Ginter, Weigl, Mkhitaryan (Kagawa 71), Castro, Reus (c) (Pulisic 61), Aubameyang. Substitutes (not used): Burki, Hummels, Sahin, Ramos.
Goals: Spurs – Son 73; Borussia Dortmund – Aubameyang 24, 71.
Yellow cards: Spurs – Lamela, Alderweireld; Borussia Dortmund – Castro.
Referee: Nicola Rizzoli (Italy).