Wales had more possession and racked up 10 efforts at goal but Andriy Yarmolenko's first half strike proved the difference.
Ben now has 19 caps to his name.
Meanwhile, Ben's fellow Spurs left-back Danny Rose looks set to make his first senior appearance for England at Wembley this evening (Tuesday, March 29).
Danny earned his first cap in the thrilling 3-2 win in Germany on Saturday and as he remains the only recognised left-back in the squad, looks likely to now line-up against the Netherlands at the national stadium.
He is one of five Spurs players in the England squad alongside Dele Alli, Eric Dier, Harry Kane and Kyle Walker - they were all on familiar territory yesterday as the Three Lions trained at Hotspur Way.
England boss Roy Hodgson is keeping his cards close to his chest in terms of a starting line-up but Kyle Walker, who remained an unused substitute in Berlin, has also been widely tipped to start against the Dutch.
However many of our quintet play, they could well find themselves up against team-mate Michel Vorm, who has been called into the Dutch squad after Ajax's Jasper Cillessen broke his nose in training.
It's an intriguing night of international action with a number of our players representing their countries - the full list is below.
Below: Danny in action for England against Germany on Saturday
Tuesday, March 29
Toby Alderweireld (in the squad but expected to miss out through illness), Nacer Chadli, Mousa Dembele - Belgium friendly against Portugal now held in Leiria, Portugal
Dele Alli, Eric Dier, Harry Kane, Danny Rose and Kyle Walker - England international friendly at home to the Netherlands
Michel Vorm - Netherlands friendly against England at Wembley
Christian Eriksen - Denmark international friendly away to Scotland
Hugo Lloris - France international friendly at home to Russia
Kevin Wimmer - Austria international friendly at home to Turkey
Josh Onomah and Kyle Walker-Peters - England Under-19s European Championship elite round qualifier against Spain in Spain
Charlie Owens - Northern Ireland Under-19s European Championship elite round qualifier against Ukraine in the Netherlands
Jaden Brown, Samuel Shashoua and Japhet Tanganga - England Under-17s home European Championship elite round qualifier against Ukraine