, Mousa Dembele and Jan Vertonghen lined-up with Belgium needing points in their second group match after losing to Italy.
Toby had a header cleared off the line as it remained goalless in the first half but Romalu Lukaku fired Belgium in front three minutes into the second half and there was no way back for ROI as Axel Witsel headed home the second and Lukaku slotted home for 3-0.
Both Toby and Jan completed the 90 minutes but Mousa was forced off with what looked like a left ankle/foot problem on 57 minutes.
Below: Touch! Jan controls the ball in Belgium's win against the Republic of Ireland
Italy top Group E on six points, Belgium are now second on three with ROI and Sweden on one each. Belgium now face Sweden in their final group game on Wednesday with ROI up against Sweden, both 8pm UK.
Kevin enters the fray
Meanwhile, Kevin Wimmer made his competitive debut for Austria as they held Ronaldo's Portugal to a goalless draw in Group F.
The central defender came on for his fourth cap at the Parc Des Princes in Paris as his side survived a missed penalty and goal disallowed from the Real Madrid star in the second half.
That result leaves Hungary top of the group on four points with Portugal and Iceland on two and Austria on one. Austria will have to beat Iceland to have any chance of progressing with the final games in Group F also on Wednesday - Austria v Iceland at the Stade de France (6pm UK).
Hugo up next
Hugo Lloris is the next Spur in action as the French skipper aims to lead his country to three wins out of three in Group A with a final group match against Switzerland in Lille on Sunday night (8pm UK).