Victory over the Cottagers at White Hart Lane will guarantee fourth place and will mean that Arsenal will have to win at West Brom to hold onto third.
Newcastle, still in the mix and a point behind in fifth, travel to Everton.
Ledley, our longest-serving player, knows better than most about the atmosphere created on these crucial days at the Lane and is calling on the fans to raise the roof again.
“Fulham are always a tough team to play against but we couldn't have asked for a better scenario than playing at home on the final day of the season, in front of our fans,” said the club captain.
“I think playing at home could make a big difference with our fans giving us that extra push.
“We have a good record at home and it’s a great opportunity for us. We don’t want to let them down.”
Ledley suspected that our destiny this season would go to the final day.
“We always knew that it would probably go down to the last game and that’s how it’s turned out,” he added.
“We’re in a good position and have a great opportunity to secure fourth place - and maybe even finish third.”