The main link is Heung-Min Son, the in-form South Korean international who joined us from the Bundesliga side in the summer of 2015. He scored 21 goals in 61 appearances for Leverkusen prior to his move to White Hart Lane.
Another member of our current squad who will be familiar to some of Leverkusen's players is defender Kevin Wimmer. Not only did the 23-year-old face our opponents twice during his time at 1. FC Köln, but three members of Leverkusen's current squad are team-mates of Kevin's in the Austrian national side – Ramazan Özcan, Aleksandar Dragović and Julian Baumgartlinger.
Dragović scored against us for FC Basel when we lost to the Swiss side in the UEFA Europa League quarter-finals in 2012-13.
Our England contingent, meanwhile, have played against Jonathan Tah (Germany) and Hakan Çalhanoğlu (Turkey, pictured, above) in international friendly matches this year.
Looking further back, Dimitar Berbatov joined us from Leverkusen in 2006 and scored 46 goals in 102 appearances in our colours before leaving for Manchester United in 2008.
We won 1-0 at Bayer Leverkusen in the group stage of the UEFA Cup in 2006-07. Berbatov (pictured, below), who had joined us from the German side a few months earlier, netted the only goal of the game.
Bayer Leverkusen were formed in 1904.
Their nickname is Werkself (Factory Team).
They won the UEFA Cup in 1988, beating Espanyol in the final.
They are competing in the UEFA Champions League group stage for a fourth consecutive season.
Leverkusen last faced English opposition in the 2013-14 UEFA Champions League group stage when they lost 5-0 at home to Manchester United.
Bayer Leverkusen have gone 10 matches unbeaten at home (W7 D3) since a 4-1 loss to Werder Bremen in March.
Former Manchester United striker Javier Hernández (pictured, below) has scored six of Leverkusen's last eight goals.
Leverkusen let slip a 2-0 lead at home to CSKA Moscow on matchday one to draw 2-2. They also led 1-0 at AS Monaco on matchday two until a 94th-minute equaliser saw the game end 1-1.
Leverkusen are currently 10th in the Bundesliga after Saturday's 2-1 defeat away to Werder Bremen. Our former defender Milos Veljkovic was on the bench for the home side.
The man in charge
Bayer Leverkusen's head coach is Roger Schmidt, the 49-year-old German who guided Red Bull Salzburg to the Austrian title in the 2013-14 season with eight games to spare. They also lifted the Austrian Cup that year. Leverkusen swooped for his services in 2014 and during his first season at the helm, he guided the team to the last 16 of the Champions League and a fourth-place finish in the Bundesliga. Last term, he steered the club to a third-place finish on the domestic scene. Schmidt (pictured, below) previously played for and managed SC Paderborn.
Leverkusen play their home matches at the 30,000-seater BayArena. The stadium was first opened in 1958, was gradually modernised throughout the late 1980s and 1990s and was expanded and renovated again between 2007 and 2009.