Tottenham travel to Merseyside on Monday night looking to maintain their fine run of form at Goodison Park that has seen them lose only once on their last nine visits.
While Everton will want to continue in the good vein of form that saw them clinch an excellent 2-1 win away at Charlton on the opening day.
Both teams currently play in the shadows of more successful cross-city rivals and two sets of supporters who are just as passionate about the game would like to redress this imbalance as soon as possible.
While Liverpool and Arsenal may both be involved in the Champions League this season, this game in front of the Sky Cameras is an opportunity to show the nation that these two former members of the 'big five' have what it takes to rejoin the Premiership elite.
New Everton skipper Kevin Campbell will lead the line for the Blues and he is sure to make it an uncomfortable evening for a rather lightweight looking Spurs defence.
The influential forward was so important to the club last season with his nine strikes helping the team to avert the possibility of relegation. His 20% goals-to-shots-ratio in 2000-01 was well above average for a top-flight striker.
SpursBet offer 5/1 on the Londoner scoring the first goal of the game on Monday night, but one man who will be standing in his way is Neil Sullivan. The Scottish international made seven saves to deny Everton a deserved victory during the corresponding fixture last January.
And Spurs' best player in 2000-01 according to the Opta rankings - after making a divisional high of 142 stops - will need to maintain such high levels of performance with Kasey Keller breathing down his neck for a place in the side.
Both Sullivan and his opposite number Paul Gerrard should not be surprised if they have to face a spot-kick on Monday night as Goodison Park was the home of the penalty last term. Nine were awarded - more than at any other ground in the Premiership.
With match referee David Elleray awarding three spot-kicks at Everton in 2000-01, players should be wary of making any rash challenges inside the box.
However both teams contain enough experienced players not to be reckless and this fixture looks like it could well light the fuse for the rest of Sky's exciting Monday night football coverage.